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Melanotan-1 (afamelanotide, [Nle4-D-Phe7]-alpha-MSH) is a synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH)

Studies have demonstrated the benefits of cyclodextrins in increasing the solubility of hydrophobic drugs, and also recent research has extended these applications to controlled drug release and use in nanotechnology

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Given this, future research should prioritize well-designed, multi-center, large-scale prospective cohort studies or randomized controlled trials